Publications

Hemarina est une société de biotechnologie qui possède une forte activité de R&D. Nos équipes possèdent un savoir faire unique, basé sur une quinzaine d'années de recherche fondamentale. Les résultats de nos travaux de recherche font l’objet de nombreux articles scientifiques publiés dans des journaux de premier plan.

Technologie Hemarina

Le Gall, T., Polard, V., Rousselot, M., Lotte, A., Raouane, M., Lehn, P., Opolon, P., Leize, E., Deutsch, E., Zal, F., Montier, T.
In vivo biodistribution and oxygenation potential of a new generation of oxygen carrier
Journal of Biotechnology, 187:1-9. - 2014
https://pubmed.ncbi.nlm.nih.gov/25034433/

Mallet, V., Dutheil, D., Polard, V., Rousselot, M., Leize, E., Hauet, T., Goujon, J.-M., Zal, F.
Dose-Ranging study of the performance of the natural oxygen transporter HEMO2life® in organ preservation.
Artificials Organs, 38(8):691-701. - 2014
https://www.ncbi.nlm.nih.gov/pubmed/24749976

Zal, F., Rousselot, M.
Extracellular Hemoglobins from Annelids, and their Potential Use in Biotechnology
Outstanding Marine Molecules, Wiley‐VCH Verlag GmbH & Co. KGaA, - 2014
https://onlinelibrary.wiley.com/doi/abs/10.1002/9783527681501.ch16

Tsai, A.G., Intaglietta, M., Sakai, H., Delpy, E., Drieu La Rochelle C., Rousselot M., Zal F.
Microcirculation and NO-CO studies of a natural extracellular hemoglobin developed for an oxygen therapeutic carrier.
Current Drug Discovery Technologies, 9(3):166-72. - 2012
https://www.ncbi.nlm.nih.gov/pubmed/22564165

Thuillier, R., Dutheil, D., Trieu, M.T.N., Mallet, V., Allain, G., Rousselot, M., Denizot, M., Goujon J.-M., Zal, F., Hauet, T.
Supplementation with a new therapeutic oxygen carrier reduces chronic fibrosis and organ dysfunction in kidney static preservation.
American Journal of Transplantation, 11(9):1845-1860. - 2011
https://www.ncbi.nlm.nih.gov/pubmed/21875432

Harnois, T., Rousselot, M., Rogniaux, H., Zal, F.
High-level production of recombinant Arenicola marina globin chains in Escherichia coli: a new generation of blood substitute.
Artif Cells Blood Substit Immobil Biotechnol., 37(3):106-16. - 2009
https://www.ncbi.nlm.nih.gov/pubmed/19444743

Bailly, X., Chabasse, C., Hourdez, S., Dewilde, S., Martial, S., Moens, L., Zal, F.
Globin gene family evolution and functional diversification in annelids.
FEBS J, 274(10):2641-52. - 2007
https://www.ncbi.nlm.nih.gov/pubmed/17451435

Chabasse, C., Bailly, X., Sanchez, S., Rousselot, M., Zal, F.
Gene structure and molecular phylogeny of the linker chains from the giant annelid hexagonal bilayer hemoglobins.
J Mol Evol, 63(3):365-74. - 2006
https://www.ncbi.nlm.nih.gov/pubmed/16838215

Chabasse, C., Bailly, X., Rousselot, M., Zal, F.
The multigenic family of the extracellular hemoglobin from the annelid polychaete Arenicola marina.
Comp Biochem Physiol B Biochem Mol Biol, 144(3):319-25. - 2006
https://www.ncbi.nlm.nih.gov/pubmed/16766219

Rousselot, M., Le Guen, D., Zal, F.
Novel dissociation mechanism of a polychaetous annelid extracellular haemoglobin.
FEBS J., 273(7):1582-96. - 2006
https://pubmed.ncbi.nlm.nih.gov/16689943/